There was no experience to this point with using METROGEL® (metronidazole topical gel) Topical Gel in pregnant individuals. Metronidazole crosses the placental barrier and enters the fetal circulation quickly.
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Metronidazole is a nitroimidazole and may be made use of with treatment in sufferers with evidence of, or history of blood dyscrasia.
In preceding medical trials submitted for accepted labeling of METROGEL-VAGINAL the next was also noted:
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Throughout pregnancy, this medication must be employed only when Obviously needed. Antibiotics taken by mouth are already utilised to deal with vaginal infections all through pregnancy, Specifically superior-danger pregnancies (as an example, when there is a risk of early childbirth). Talk to your physician For additional specifics and to discuss the pitfalls and Positive aspects.
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There have been no experience so far with the usage of METROGEL-VAGINAL in pregnant people. Metronidazole crosses the placental barrier and enters the fetal circulation promptly. No fetotoxicity or teratogenicity was noticed when metronidazole was administered orally to jnetoto pregnant mice at 6 situations the encouraged human dose (based on mg/m2); however, in one little review in which the drug was administered intraperitoneally, some intrauterine deaths were being noticed. The relationship of such findings for the drug is not known.
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